Non-invasive VNS Effects on Hyperarousal and Autonomic State in Patients with PTSD
Journal: Frontiers in Medicine (2017) Authors: Damon G. Lamb, Eric C. Porges, Greg F. Lewis and John B. Williamson Background: ...
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science
Trial
Results
Patients in our pilot study were some of the first to wear the Phoenix® and experience the relief it can provide.
The results from our pilot study are listed below.
If you would like to learn more, please contact us.
What is VNS?
Vagus nerve stimulation (VNS) is a type of neuromodulation, which is a treatment that alters the activity of nerves. Vagus nerve stimulation involves implanting a device that sends regular, mild pulses of electrical energy to your brainstem through your vagus nerve in your neck. After reaching your brainstem, the electrical charge is discharged to different areas of your brain to change the way brain cells work.
What is the Vagus nerve?
The vagus nerve, also known as the vagal nerves, are the main nerves of your parasympathetic nervous system. This system controls specific body functions such as your digestion, heart rate and immune system. These functions are involuntary, meaning you can’t consciously control them.
VNS Research
The vagus nerve is critical in many therapeutic areas. It's beneficial in restoring balance to sympathetic activity that is abnormally raised, or parasympathetic activity that is lowered.
A sample of what researchers are investigating:
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VNS mechanisms of action
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Restoration of autonomic balance
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Laying new neural pathways during tasks
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Reduction of symptoms and systemic inflammatory responses
PILOT TRIAL RESULTS
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PTSD
The FDA requires a 50% responder rate and an average 6 pt reduction in the CAPS-5.
The Phoenix exceeded these requirements and provided an average 18.4 pt reduction in CAPS-5, with only 1 non-responder and 1 non-compliant participant. These results were statistically and clinically significant with a p-value of .0100 and a 95%CI: 0.57, 0.98.
Quality of Life
The Promis-29 looks at 7 aspects of quality of life and compares responses to the general population to determine severity of responses.
Clinical research
Clinical Research
Support
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Assist with protocol development
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Full training and installation
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Clinical support
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IT support for data collection, download and interpretation
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Repair, maintenance and replacement
“What do I have to lose? It’s not a drug that I’m putting in my system and its not something that I’m smoking. So, if you’re telling me that you can put something in my ear and make me better, sign me up every day of the week!”
-Pilot Study Participant
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